Potensi Senyawa Kimia Ekstrak Etanol Kelakai (Stenochlaena palustris) sebagai Antitrombotik

Indah Saputri; Indah Setiawati; Mukarramah Mukarramah; Windy Sidratul An’nisa; Nor Afni Afdella; Noer Komari

doi:10.58996/hmj.v7i2.129

Indah Saputri Program Studi Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat Banjarbaru, Kalimantan Selatan, Indonesia
Indah Setiawati Program Studi Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat Banjarbaru, Kalimantan Selatan, Indonesia
Mukarramah Mukarramah Program Studi Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat Banjarbaru, Kalimantan Selatan, Indonesia
Windy Sidratul An’nisa Program Studi Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat Banjarbaru, Kalimantan Selatan, Indonesia
Nor Afni Afdella Program Studi Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat Banjarbaru, Kalimantan Selatan, Indonesia
Noer Komari Program Studi Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat Banjarbaru, Kalimantan Selatan, Indonesia

DOI: https://doi.org/10.58996/hmj.v7i2.129

Keywords: antithrombin, molecular docking, virtual screening, kelakai

Abstract

Damage to blood vessels begins with the formation of platelet aggregation which then forms a thrombus in the artery, resulting in disruption of blood flow. Many efforts have been made to prevent platelet aggregation using herbal medicines. Kelakai is a typical Kalimantan plant thought to have antithrombotic potential. The aim of this research is to identify the potential of kelakai ethanol extract compounds as antithrombotics through in silico studies using virtual screening and molecular docking. The kelakai compound was obtained from GC-MS data taken from the ethanol extract of kelakai. The virtual screening results showed that the results of GC-MS analysis of ethanol extract found five compounds that had the potential to be antithrombotic. Molecular docking simulations with the antithrombin receptor protein (PDB ID: 1E04) show that the n-Hexadecanoic acid compound from kelakai ethanol extract has the lowest ∆G value of -8.72 kcal/mol. The n-Hexadecanoic acid compound from kelakai has potential as an antithrombotic.